An haife shi a Najeriya, Osimhen ya fara babban aikinsa a Jamus a VfL Wolfsburg a cikin 2017.[7] Bayan kakar wasa daya da rabi a kulob din, ya koma kulob din Charleroi na Belgium a matsayin aro a cikin 2018-19, kafin ya koma Ligue 1 tare da Lille, inda ya ci kwallaye goma sha takwas a kakarsa ta farko tare da kulob din Faransa. A cikin 2020, Osimhen ya koma Napoli ta Serie A kan kuɗin rikodin kulob na Yuro miliyan 70, kuma ya lashe kyautar mafi kyawun matashin ɗan wasan Seria A a kakar 2021-22. A kamfen na gaba, ya kammala a matsayin wanda ya fi zura kwallaye a gasar lig da kwallaye 26, wanda ya zama tarihi ga dan wasan Afrika, yayin da ya taimaka wa Napoli ta lashe kofin Seria A na farko na tsawon shekaru 33. Domin kokarinsa, ya lashe kyautar Gwarzon dan wasan gaba na gasar, kafin kuma a ba shi kyautar Gwarzon Kwallon Kafa na Seria A bayan 'yan watanni. A halin yanzu Osimhen shine dan wasan Afirka mafi yawan zura kwallaye a tarihin Seria A.[8][9] Osimhen ya lashe kyautar takalmi...